Leonardo da Vinci (Vinci, 1452 - Amboise, 1519) is one of the most important men of Renaissance. He worked as artist and engineer spending the most of his life between Florence and Milan, where he painted “Last Supper”, one of the masterpieces of Renaissance art. Science and art are strongly related in Leonardo’s activity and are influenced by the deep curiosity and observation of man and nature. The thousands of notes and drawings he left in his manuscripts and codices witness the variety of his interests. His studies ranged from painting to engineering, from architecture to mechanics, from physics to anatomy.